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    We are keen on the extraction, development and research of plant drugs. Natural plant extracts are the deep processing of natural biomass, and have the advantages and characteristics of less development investment, high technical content, large added value of products, and extensive international markets.

    my country's plant extract industry is still in the early stages of development, with a small scale and weak competitiveness. It basically provides raw materials for botanical medicines or other industries in the more developed countries. my country's factories obtain only very low profits.

    Our brother company "Shanghai Chimoph Pharmaceutical Co., Ltd." (http://www.chimoph.com) has obtained marketing authorization for plant extracts such as vinblastine, vincristine, colchicine, reserpine and licorice, etc. ;

    Take paclitaxel as an example:

    Paclitaxel was extracted from the bark of Pacific brevifolia yew at the end of the 1960s by the National Cancer Institute of the United States, and the diterpenoid compound with a taxene ring was obtained after separation. After more than 30 years of development by NCI and Bristol-Myers Squibb, it was approved by the FDA for listing in December 1992 and has now been listed in more than 50 countries around the world.

    The other is semi-synthetic made from the bark of various yew trees and "10-bacillus gibberellin" extracted from the branches of ornamental yew, namely docetaxel (docetaxel), its structure and natural The extraction of paclitaxel is very similar.

    Paclitaxel is a cytostatic anti-tumor drug that can interfere with the synthesis of tubulin in cancer cells to exert anti-tumor effects. It has basically no effect on normal cells. It has a strong inhibitory effect on most solid tumors, especially for advanced ovarian cancer, breast cancer, non-small cell lung cancer and Kaposi’s sarcoma. It has definite curative effect and less side effects. At the same time, it is also used for rheumatoid arthritis and skin. Treatment of illness. The product is mainly injections, supplemented by powder injections, capsules, and gels.

    The improvement of the production process of paclitaxel mainly focuses on two aspects. The first is the change in the source of raw materials, from the initial wild resources to artificial cultivation, and then to the cell culture extraction developed by BMS. However, the cell culture method is not yet fully mature, and the main source of raw materials in the market is still It is mainly artificial planting, and the control of resources has become a company's competitive advantage to a certain extent. The second is the extraction and modification of paclitaxel intermediates. Different intermediates are selected. The yield of paclitaxel per ton of yew varies greatly. Choosing better intermediates and developing effective extraction and truth-seeking technologies are crucial to the improvement of production efficiency.